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Research Topics
My research focuses on the intersection of artificial intelligence for healthcare, computational clinical research, and wearable devices, with a particular interest in multimodal learning for healthcare and physiological signal analysis. The goal of my research is to investigate how machine learning frameworks can be used to aid, understand and integrate multimodal clinical medical data.
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Selected Publications
(* equal contribution)
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An electrocardiogram foundation model built on over 10 million recordings
Jun Li, Aaron D Aguirre, Valdery Moura Junior, Jiarui Jin, Che Liu, Lanhai Zhong, Chenxi Sun, Gari Clifford, M Brandon Westover, Shenda Hong
NEJM AI, 2025
Paper
This study introduces ECGFounder, a general-purpose electrocardiogram foundation model pretrained on over 10 million recordings to enhance cardiovascular disease assessment. By employing a unified framework for both single-lead and multilead data, the model achieves state-of-the-art performance and robust generalization across diverse downstream clinical diagnostic tasks.
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Expert-level detection of epilepsy markers in EEG on short and long timescales
Jun Li, Daniel M Goldenholz, Moritz Alkofer, Chenxi Sun, Fabio A Nascimento, Jonathan J Halford, Brian C Dean, Mattia Galanti, Aaron F Struck, Adam S Greenblatt, Alice D Lam, Aline Herlopian, Chinasa Nwankwo, Dan Weber, Douglas Maus, Hiba A Haider, Ioannis Karakis, Ji Yeoun Yoo, Marcus C Ng, Olga Selioutski, Olga Taraschenko, Gamaleldin Osman, Roohi Katyal, Sarah E Schmitt, Selim Benbadis, Sydney S Cash, William O Tatum, Zubeda Sheikh, Wan Yee Kong, Grace Bayas, Niels Turley, Shenda Hong, M Brandon Westover, Jin Jing
NEJM AI, 2025
Paper
This study presents an AI system--SpikeNet2 that achieves expert-level accuracy in detecting epileptiform discharges within EEG recordings. By operating across both short and long timescales, the model effectively identifies specific epilepsy markers and predicts long-term seizure risk to assist in clinical diagnosis.
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Frozen language model helps ecg zero-shot learning
Jun Li*, Che Liu*, Sibo Cheng, Rossella Arcucci, Shenda Hong
Medical Image in Deep Learning (MIDL), 2023,(Oral Presentaion)
Paper
This study introduces a cross-modal training framework that aligns electrocardiogram (ECG) signals with natural language reports using a frozen language model to achieve zero-shot classification. By leveraging the semantic knowledge of a pre-trained language model, the proposed method enables the identification of heart diseases without requiring any annotated samples for new diagnostic categories.
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EEG Detection and Prediction of Freezing of Gait in Parkinson's Disease Based on Spatiotemporal Coherent Modes
Jun Li, Yuzhu Guo
IEEE Journal of Biomedical and Health Informatics (JBHI), 2023
Paper
This study introduces a novel EEG-based method combining dynamic mode decomposition and analytic common spatial patterns (DMD-ACSP) to accurately detect and predict freezing of gait in Parkinson's disease. By extracting dynamic spatiotemporal coherent modes of brain activity, the approach significantly improves predictive performance and provides valuable insights for personalized clinical interventions.
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JiZou Intelligence —— Intelligent Piano Education System 「极奏智能」
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Video
An Intelligent Piano Education System based on the multi-modal deep learning. Computer vision, Music AI and photoelectric sensors are used to improve the quality of piano teaching.
Committed to promoting piano education to children who are not rich but love piano.
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